Marvel Nemesis: Rise Of The Imperfects
- Play as Brigade
- Successfully complete Campaign mode with The Thing to unlock Brigade. -From: William Fries IV
- Play as Captain America
- Successfully complete Campaign mode with Fault Zone to unlock Captain America.
- Play as Iron Man
- Successfully complete Campaign mode with Johnny Ohm to unlock Iron Man.
- Play as Magneto
- Successfully complete Campaign mode with Venom to unlock Magneto. -From: William Fries IV
- Play as Solara
- Successfully complete Campaign mode with Spider-Man to unlock Solara. -From: William Fries IV
- Play as Spider-Man
- Successfully complete Campaign mode with Brigade to unlock Spider-Man. -From: William Fries IV
- Play as Venom
- Successfully complete Campaign mode with Iron Man to unlock Venom. -From: William Fries IV
- Play as The Wink
- Successfully complete Campaign mode with Magneto to unlock The Wink.
- Play as Wolverine
- Successfully complete Campaign mode with Solara to unlock Wolverine. -From: William Fries IV
- Third card slot
- Successfully complete Campaign mode with one character to unlock the third card slot. -From: William Fries IV
- Fourth card slot
- Successfully complete Campaign mode with two different characters to unlock the fourth card slot. -From: William Fries IV
- Uber cards
- Successfully complete a character's Campaign mode with a gold rank in each match to unlock a "Master Unlock" rarity card.
- Recharge super power faster
- Hold R and stand still. Do not walk or run and your super power (blue line) will refill quicker.