- S.C.A.R.S.
- S.T.A.L.K.E.R.: Shadow Of Chernobyl
- S.W.I.N.E.
- Sabre Team
- Sacred
- Sacrifice
- Sam And Max Hit The Road
- Sam And Max: Episode 1 - Culture Shock
- Sam And Max: Episode 2 - Situation: Comedy
- Sam And Max: Episode 3 - The Mole, The Mob And The Meatball
- Sam And Max: Episode 4 - Abe Lincoln Must Die!
- Sam And Max: Episode 5 - Reality 2.0
- Sam And Max: Episode 6 - Bright Side Of The Moon
- Sandwarriors
- Sanity: Aiken's Artifact
- Sarakon
- Saturday Night Speedway
- Savage: The Battle For Newerth
- Scarface: The World Is Yours
- School Tycoon
- Scorch
- Scrapland
- Scratches
- Screamer Rally
- Sea Dogs
- Sea Of Fire
- SeaWorld Adventure Parks Tycoon
- SeaWorld Adventure Parks Tycoon 2
- Second Sight
- Secret Of The Silver Earring
- Secret Service 2: Security Breach
- Secret Service: In Harms Way
- Secret Weapons Over Normandy
- Sega Rally Championship
- Sensible Soccer '98
- Sensible Soccer 2006
- Sensible World Of Soccer
- Septerra Core: Legacy Of The Creator
- Serious Sam
- Serious Sam 2
- Serious Sam: The Second Encounter
- Settlers 2, The
- Settlers 2, The: Gold Edition
- Settlers 3, The
- Settlers 4, The
- Seven Kingdoms
- Seven Kingdoms 2: The Fryhtan Wars
- Severance: Blade Of Darkness
- Shadow Company
- Shadow Force: Razor Unit
- Shadow Man
- Shadow Master
- Shadow Warrior
- Shadowgrounds
- Shadowrun
- Shattered Union
- ShellShock: Nam '67
- Ship, The
- Shogo: Mobile Armor Division
- Shogun: Total War
- Shogun: Total War - Warlord Edition
- Shrek 2
- Shrine Circus Tycoon
- Sid Meier's Alpha Centauri
- Sid Meier's Alpha Centauri: Alien Crossfire
- Sid Meier's Pirates!
- Silent Hill 4: The Room
- Silent Hunter 3
- Silent Hunter: Wolves Of The Pacific
- Silent Storm
- Silverfall
- Sim Theme Park
- SimAnt
- SimCity 2000
- SimCity 2000: Network Edition
- SimCity 3000
- SimCity 3000 Unlimited
- SimCity 4
- SimCity Classic
- SimCity Urban Renewal Kit
- SimCoaster
- SimCopter
- SimEarth
- SimFarm
- SimGolf
- SimIsle
- SimLife
- SimPark
- Sims 2, The
- Sims 2, The: Celebration Stuff
- Sims 2, The: Family Fun Stuff
- Sims 2, The: Glamour Life Stuff
- Sims 2, The: Happy Holiday Stuff
- Sims 2, The: Holiday Edition
- Sims 2, The: Nightlife
- Sims 2, The: Open For Business
- Sims 2, The: Pets
- Sims 2, The: Seasons
- Sims 2, The: University
- Sims, The
- Sims, The: Hot Date
- Sims, The: House Party
- Sims, The: Life Stories
- Sims, The: Livin' Large
- Sims, The: Makin' Magic
- Sims, The: Superstar
- Sims, The: Unleashed
- Sims, The: Vacation
- SimSafari
- SimTower
- SimTown
- SiN
- SiN Episodes: Emergence
- Singles 2: Triple Trouble
- Singles: Flirt Up Your Life
- Sinistar Unleashed
- Sitting Ducks
- Ski Resort Tycoon
- Ski Resort Tycoon 2
- Ski-Doo: X-Team Racing
- Slave Zero
- Small Soldiers
- Smugglers 3
- Sniper Elite
- Snoopy vs. The Red Baron
- Snow Day: The GapKids Quest
- Snowboard Park Tycoon