- Earth 2150
- Earth 2160
- Earthworm Jim
- Earthworm Jim 2
- Echelon
- Economic War
- Ed, Edd n Eddy: The Mis-Edventures
- El Matador
- Elder Scrolls 3, The: Bloodmoon
- Elder Scrolls 3, The: Morrowind
- Elder Scrolls 4, The: Knights Of The Nine
- Elder Scrolls 4, The: Oblivion
- Elder Scrolls 4, The: Shivering Isles
- Elder Scrolls, The: Daggerfall
- Elder Scrolls, The: Redguard
- Elf Girl Sim Date 2
- Elite Warriors: Vietnam
- Emergency 2: The Ultimate Fight For Life
- Emergency 3
- Emergency 4 Deluxe
- Emergency Room
- Emergency: Fighters For Life
- Emergency: Fire Response
- Empire Earth
- Empire Earth 2
- Empire Earth 2: The Art Of Supremacy
- Empire Earth: The Art Of Conquest
- Empire Of The Ants
- Empires: Dawn Of The Modern World
- Enclave